Drug–drug interactions in neonatal intensive care: A prospective cohort study

BackgroundTo characterize the prevalence and profile of drug–drug interactions (DDIs), drugs most related to major DDIs risk factors their prescription in a neonatal intensive care unit (NICU).MethodsNeonates admitted NICU who had at least one medication prescribed hospital stay >24 h were included prospective cohort study (August 2017 July 2018). All medications during hospitalization collected from all neonates (n = 220), with screening for DDIs. Prevalence type was identified. Network analysis used identify more implicated Logistic regression (p < 0.05).ResultsOver 70% exposed 29% The network identified furosemide, fentanyl, aminophylline fluconazole as DDI, fentanyl especially associated number (OR 1.60, p 0.01), caesarean delivery 2.68, 0.05), gestational age 1.03, 0.01) APGAR score 0.78, exposure DDI.ConclusionNeonates have high occurrence is specifically fentanyl. drugs, age, cesarean low first minute NICU. To (NICU). Neonates 0.05). Over DDI.